Adding a certain compound to certain chemical reactions, such as: 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 76801-93-9, SDS of cas: 76801-93-9
In a three-necked flask equipped with a stirrer and a reflux condenser, a solution of 5-amino-N, N-bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (84.6 g, 0.12 mol) N,N’-dimethyl acetamide 172ml, stirring, heating to 50 C dissolved, cooled to 10 C, add chloroacetyl chloride 62ml (88.09g, 0.78mol) dropwise for about 30 minutes, heated to 50 C stirring for 3h, cooling to 0 ~ 10 C, at 10 C, dropping 10mol / L sodium hydroxide solution 156ml, room temperature stirring 1h. After adding 100 ml of water, 59 ml of 1N hydrochloric acid was added dropwise, and the mixture was allowed to stand overnight. The filtrate was washed with water and dried to give 83.2 g of a yield of 90.0%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Hengrui Medicine Co., Ltd.; Hou, Xianshan; Wang, Junyan; (11 pag.)CN106336362; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com