In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 58755-70-7 as follows. name: 1-Iodo-4-methoxy-2-nitrobenzene
To a solution of 4-iodo-3-nitroanisole (5g, 17.9 mmole) in 100 [ML METHANOL] was added [FECL3] (50mg, 0.3 mmole) and activated carbon (40 mg). The mixture was heated to reflux and hydrazine hydrate (1.75 [G,] 35 mmole) was added dropwise. The mixture was [REFLUXED] for an additional 8 hours and cooled to room temperature, filtered through Celite. The filtrate was concentrated and purified by column chromatography (eluting with 10% EtOAc in hexanes) to give 4.05 g product as pale yellow oil (91% [YILD). 1H NMR (300 MHZ, CDCL3) No. 7. ]47 [(1 H,] d, J = 8.7 Hz), 6.31 (1H, d, [J=] 2.8 [HZ),] 6.13 (1 H, dd, [J=] 2.8, 8.7 Hz), 3.73 (3H, s).
According to the analysis of related databases, 58755-70-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; WO2003/106462; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com