34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 34883-46-0
(1)To 1-iodo-2-phenoxybenzene (2g, 6.8mmol)Triethylamine (20mL)Adding 4 methoxyphenylacetylene to the solution(0.98 g, 7.4 mmol), Pd(PPh3)2Cl2 (95 mg, 135 mumol), CuI (26 mg, 135 mumol).Under argon protection conditions,After the reaction was carried out for 10 h, triethylamine was removed under reduced pressure.The residue was extracted with ethyl acetate (20 mL×3) then water (10 mL)Wash twice with saturated brine (10 mL), dry over anhydrous sodium sulfate and filtered.The solvent was removed under pressure. The residue was purified by silica gel column chromatography eluting elut1-((4-Methoxyphenyl)ethynyl)-2-phenoxybenzene(1.7 g, 85% yield).
The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhongshan University Tumor Cure Center (Zhongshan University Affiliated Tumor Hospital ? Zhongshan University Tumor Institute); Wen Shijun; Huang Peng; Zhu Daqian; Tu Yalin; Luo Bingling; (28 pag.)CN108976248; (2018); A;,
Iodide – Wikipedia,
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