Simple exploration of

Some common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, molecular formula is C9H11I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H11I

A solution of Pd(PPh3)2Cl2 (0.26 g, 0.41 mmol), triethylamine (1.7 mL, 12.2 mmol), l-iodo-2-isopropylbenzene (1.0 g, 4.1 mmol), CuI (0.077 g, 0.41 mmol) and trimethylsilylacetylene (0.19 g, 0.81 mmol) in DMF (15 mL) was heated for 30 min at 80 0C. The resulting mixture was concentrated and purified by silica gel chromatography using hexanes to afford the title compound as yellow oil (0.85 g, 97%). [0154] 1H NMR (500 MHz, DMSO-J6): delta 0.23 (s, 9H), 1.20 (d, J = 7.0 Hz, 6H), 3.35 (qn, J = 6.9 Hz, IH), 7.17 (td, J = 7.3, 1.8 Hz, IH), 7.31-7.39 (m, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19099-54-8, its application will become more common.

Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com