Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,1,1-Trifluoro-3-iodopropane
At room temperature, 190 g (1.4 mol) of potassium carbonate was weighed into 3 L of a three-necked flask and 500 g of DMF was added,100 g (0.7 mol) of compound 16 was added and stirring was started,20-25 C was added dropwise with 205 g (0.916 mol) of trifluoroproponium chloride, After the addition of stirring for 4.5h, the TLC reaction was completed. Add 1.6kg of methanol, stir for 30min,Suction filter. The filter cake was washed twice with methanol twice. Decompression steamed filtrate to no liquid,To the residue was added 1.5 kg of water, and 1N hydrochloric acid solution was added thereto to adjust the pH to 7,Ice bath 0 ~ 3 stirring 3h, filter, 45 drying to get 137g product, the yield of 81.8%Purity HPLC: 98.5%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 460-37-7.
Reference:
Patent; Beijing Guangbo Desai Pharmaceutical Technology Development Co., Ltd.; Yitai (Beijing) Pharmatech Co., Ltd.; Wu, Yuan; Tian, Hua; (14 pag.)CN106008633; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com