116632-39-4, name is 5-Bromo-2-iodotoluene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H6BrI
5-bromo-l-(bromomethyl)-2-iodobenzene (15a). A solution of 5-bromo-2- iodotoluene (6.75 g, 22.7 mmol) and 1,2-dichlorethane (25 mL) was stirred at room temperature in a 50 mL two neck round bottom under nitrogen. Benzoyl peroxide (281 mg, 1.14 mmol) and NBS (4.5 g, 25 mmol) were added at once and the resulting mixture was heated to reflux and irradiated with a 250 W incandescent flood lamp (12 in away from round bottom) for 5 h. The reaction mixture was allowed to cool to room temperature after which precipitates were filtered off and rinsed with hexane. The filtrate was dried with MgS04, filtered and the solvent removed under reduced pressure to provide an orange solid that was then rinsed with cold methanol yielding 3.99 g (10.6 mmol, 47%) of an off-white solid that was used without further purification. Characterization data matched that found in literature. Amijs, C. H. M, et al, Green Chem. 2003, 5, 470-474.
The synthetic route of 116632-39-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE JOHNS HOPKINS UNIVERSITY; TOVAR, John Dayton; CARUSO, Jr., Anthony; WO2011/127383; (2011); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com