Related Products of 351003-36-6,Some common heterocyclic compound, 351003-36-6, name is 2-Fluoro-5-iodobenzonitrile, molecular formula is C7H3FIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of tert-butyl 4-ethynyl-4-hydroxypiperidine-1-carboxylate (8.2 g, 36 mmol) and 2-fluoro-5-iodobenzonitrile(8.72 g, 43.6 mmol) in N,N-diethylamine (200 mL), was added tetrakis(triphenylphosphine)palladium dichloride(0.80 mg) and copper (I) iodide (0.34 mg). The mixture was stirred at room temperature under N2 for 12 h and thenevaporated. The residue was partitioned between water and EtOAc. The combined organic solutions were washed withbrine (500 mL), dried (Na2SO4), filtered and concentrated to provide tert-butyl 4-[(3-cyano-4-fluorophenyl)ethynyl]-4-hydroxypiperidine-1-carboxylate which was used directly in the next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Fluoro-5-iodobenzonitrile, its application will become more common.
Reference:
Patent; Merck Sharp & Dohme Corp.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; (136 pag.)EP2755656; (2016); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com