In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27913-58-2, name is 4-(4-Iodophenyl)butanoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H11IO2
[0240] A flask was charged with 4-(p-iodophenyl)butyric acid (600 mg, 2.07 mmol), DCC (427 mg, 2.07 mmol), and N-hydroxysuccinimide (238 mg, 2.07 mmol). Diehl or omethane (6 mL) was added, and the reaction stirred at room temperature for 4 h. Filtering the reaction mixture through a short celite pad, rinsing the pad with dichl or omethane (5 mL), and removing the solvent under vacuum provided crude 4- (p-iodophenyl)butyric acid NHS ester. To this was added DMF (8 mL), 4- aminobutyric acid (525 mg, 5.19 mmol), and diisopropylethylamine (2 mL). The reaction was stirred at room temperature for 24 h, then loaded onto a 100 g Cl 8 Isco gold column. Eluting with 15% to 85% acetonitrile in water with 0.1% TFA provided 70 (560 mg, 1.49 mmol, 72% yield).
The synthetic route of 27913-58-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARVEDA THERAPEUTICS, INC.; BILODEAU, Mark T.; MOREAU, Benoit; KADIYALA, Sudhakar; WOOSTER, Richard; WHITE, Brian H.; (102 pag.)WO2019/195384; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com