Synthetic Route of 42861-71-2, A common heterocyclic compound, 42861-71-2, name is 3-Iodophenyl acetate, molecular formula is C8H7IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 3-iodophenyl acetate (5.6g) (J. Org. Chem. 1983,48, 1542-4) in acetonitrile (100mL) was treated with (Ph3P) 2PdCt2 (673mg) and Cul (368mg) and stirred at room temperature. 3-Butyn-1-ol (1.78g) was added and the reaction mixture stirred for a further 20 h and concentrated in vacuo. The residue was purified by chromatography (SPE, gradient from cyclohexane to DCM) to give the title compound. LCMS RT= 2.54 min
The synthetic route of 42861-71-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2003/91204; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com