A common compound: 645-00-1, name is 1-Iodo-3-nitrobenzene, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 645-00-1
General procedure: A round bottom flask was charged with aryl halide (0.5 mmol) and terminal acetylene (0.6 mmol). To the mixture, Pd(OAc)2 (1 mol%), A4 (2 mol%) andK2CO3 (1.5 mmol) were added. The reaction mixture was stirred at roomtemperature in EtOH (4 mL) for the mentioned time. The formation of theproduct was confirmed by monitoring the TLC. The reaction mixture was thenextracted with ethyl acetate (3 10 mL). The extracted layer was dried overNa2SO4 and concentrated in rotary evaporator. The crude product was purifiedby column chromatography over silica gel (Eluent: n-hexane) to obtain thedesired product. The pure products were confirmed by 1H and 13C NMR.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 645-00-1, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Das, Sameeran Kumar; Sarmah, Manashi; Bora, Utpal; Tetrahedron Letters; vol. 58; 22; (2017); p. 2094 – 2097;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com