82998-57-0, The chemical industry reduces the impact on the environment during synthesis 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, I believe this compound will play a more active role in future production and life.
General procedure: To mixture of compound N-(2-chloro-6-methylphenyl)-2-{[6-[4(1-piperazinyl)-2-methyl -4-pyrimidinyl]amino]-5-thiazolecarboxamide (6) (5.1 mol equivalent), the corresponding carboxylic acid (1:1 mol equivalents), DCC (1:1 molequivalents) and oxyma (1:1 mol equivalents) were charged into 4-necked round bottomed flask along with tetrahydrofuran.The slurry was slowly heated at 63-65 C for 4-5 h. Then cooled slowly to room temperature. The reaction mixture was quenched into demineralized water. The obtained solid was collected by vacuum filtration, washed with demineralized water. Suckdried thoroughly to afford crude product. The above obtainedcrude product was dissolved in hot dimethyl sulfoxide (DMSO) (5 volumes to compound weight) and charcoal treatment was given. The hot solution was slowly diluted with water (6 volumes to DMSO quantity) and cooled slowly to room temperature. The solid was colected by vacuum filtration and washed with 10 mL of demineralized water. Drying of the wet compound to get a white coloured product.
The chemical industry reduces the impact on the environment during synthesis 3-Iodo-4-methylbenzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Article; Buchappa; Durgaprasad; Suneelkumar; Rani, P. Baby; Babu, K. Ravi; Rao, A. K. S. Bhujanga; Aparna; Asian Journal of Chemistry; vol. 28; 6; (2016); p. 1275 – 1280;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com