Application of 72373-82-1, These common heterocyclic compound, 72373-82-1, name is 1-Chloro-2-fluoro-3-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compounds dibenzo[b,d]furan-2-ol (30g, 0.16mol), 1-chloro-2-fluoro-3-iodo-benzene (41.7g, 0.16mol) in 300ml DMF in a nitrogen atmosphere completely After dissolving, potassium carbonate (44.2 g, 0.32 mol) was added and the mixture was heated with stirring for 2 hours. The temperature was lowered to room temperature, and water was added to obtain a solid, which was purified by column chromatography (chloroform / hexane) to give Compound 1-A (60.5 g, yield: 90percent)
Statistics shows that 1-Chloro-2-fluoro-3-iodobenzene is playing an increasingly important role. we look forward to future research findings about 72373-82-1.
Reference:
Patent; LG Chem, Ltd.; Yoon Hong-sik; Hong Wan-pyo; Jeong Gyeong-seok; Kim Yeon-hwan; Yoon Hong-je; (49 pag.)KR2018/101265; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com