Electric Literature of 1878-94-0,Some common heterocyclic compound, 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, molecular formula is C8H7IO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: An equimolar mixtures of 4-amino-6-tert-butyl-3-mercapto-1,2,4-triazine-5(H)-one (0.01mol) (3) and substituted aryloxyacetic acids (0.01mol) (4) were condensed in presence of POCl3 at 90C, for 8h. The reactions were carried out in dry condition. The reaction mixtures were cooled and poured into crushed ice drop wise with vigorous shaking, yielded solid product, filtered and recrystallized from ethanol to afford analytical samples (5a-5n) (Scheme 2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Iodophenoxy)acetic acid, its application will become more common.
Reference:
Article; Castelino, Prakash Anil; Naik, Prashantha; Dasappa, Jagadeesh Prasad; Sujayraj; Sharath Chandra; Chaluvaiah, Kumara; Nair, Ramya; Sandya Kumari; Kalthur, Guruprasad; Adiga, Satish Kumar; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 194 – 199;,
Iodide – Wikipedia,
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