Synthetic Route of 4387-36-4, The chemical industry reduces the impact on the environment during synthesis 4387-36-4, name is 2-Iodobenzonitrile, I believe this compound will play a more active role in future production and life.
2-{[(4alphaS)-l-(4-Fluorophenyl)-5-hydroxy-4alpha-methyl-l,4,4alpha,5,6,7-hexahydrocyclopenta[fJindazol-5- yl]ethynyl}benzonitrile (20-1). Disopropylamine (0.052 mL, 0.364 mmol) was added to a solution of 1-6 (112 mg, 0.363 mmol), 2-iodobenzonitrile (113 mg, 0.401 mmol), bis(triphenylphosphine)palladium30 (II) chloride (5.10 mg, 0.008 mmol), and CuI (1.38 mg, 0.008 mmol) in anhydrous THF (1.0 mL) at ambient temperature. The resulting solution was stirred at ambient temperature for 2.0 hours, then diluted with diethyl ether, filtered through a pad of celite and the solvent removed in vacuo. Purification by flash chromatography on 40 g of silica, eluting with a gradient of 0-90percent EtOAc in hexanes afforded 50 mg, 33 percent of 20-1 as a yellow foamy solid. MS (ESI): m/z = 410.2 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2008/51532; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com