6940-76-7, name is 1-Chloro-3-iodopropane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Chloro-3-iodopropane
General procedure: 1-Boc-piperazine (2 g, 10.74 mmol, 1.0 equiv) was combined with K2CO3 (5 equiv) in DMF (10 mL), followed by 1-Chloro-3-iodoproprane (1.0 equiv) and the mixture was stirred at 50 C for 1 h. The reaction progress was monitored by LC-MS and upon completion of the reaction 4-cyanophenol (1.2 equiv) and sodium iodide (0.1 equiv) was added and the reaction allowed to stir at 70 C for 2 h. The mixture was poured onto water and extracted with EtOAc, washed with brine and dried over Na2SO4. The volatiles were removed under reduced pressure and the crude mixture purified on silica gel (60 – 90 C PE : EtOAc = 3:1) to provide the desired product.
The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ren, Jing; Xu, Wei; Tang, Le; Su, Minbo; Chen, Danqi; Chen, Yue-Lei; Zang, Yi; Li, Jia; Shen, Jingkang; Zhou, Yubo; Xiong, Bing; Bioorganic and Medicinal Chemistry Letters; vol. 26; 18; (2016); p. 4472 – 4476;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com