Application of 444-29-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Pd(OAc)2 (45 mg; 0.2 mmol) and triphenylphosphine (115 mg; 0.44 mmol) were filled into anoven dried sealable tube and dissolved in dry MeCN (12 mL) under argon atmosphere. After5 min Cs2CO3 (3.26 g; 10 mmol), the aryl iodide (2 mmol), 1,3-dibromopropane (2.04 mL;20 mmol; for iodobenzene (1a): 2.24 mL; 22 mmol) and methylacrylate (906 muL; 10 mmol)were added. The reaction mixture was purged with argon for 5 min. After addition ofnorbornene (942 mg; 10 mmol) the tube was sealed and heated at 90 °C for 18 h.For workup the cooled reaction mixture was filtered over Celite®, washed with DCM,concentrated in vacuo and purified by column chromatography.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Stark, Tina; Suhartono, Marcel; Goebel, Michael W.; Lautens, Mark; Synlett; vol. 24; 20; (2013); p. 2730 – 2734;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com