Adding a certain compound to certain chemical reactions, such as: 351003-36-6, name is 2-Fluoro-5-iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 351003-36-6, Recommanded Product: 351003-36-6
Step 1: General procedure A was followed using 2-fluoro-5-iodo-benzonitrile as aryl iodide to afford (R)-2-fluoro-5-[3-(1-naphthalen-1-yl-ethylamino)-prop-1-ynyl]-benzonitrile. The product was purified by chromatography using 0-5% methanol in DCM, affording (R)-2-fluoro-5-[3-(1-naphthalen-1-yl-ethylamino)-prop-1-ynyl]-benzonitrile.
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Reference:
Patent; LEO PHARMA A/S; US2012/101039; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com