Synthetic Route of 455-13-0, A common heterocyclic compound, 455-13-0, name is 4-Iodobenzotrifluoride, molecular formula is C7H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of H2O (5 ml) were added CuI (0.1 mmol, 19 mg), aryl halides (1.0 mmol),nitrogen nucleophiles (1.2 mmol), Cs2CO3 (2 mmol, 651 mg) and L5 (0.1 mmol) were added tothe solution, subsequently the mixture was heated to 100 C under air and stirred for 24 h. Whenthe reaction was finished, the mixture was cooled and partitioned by adding the ethyl acetate (20ml) and water (20 ml). Then, the organic phase was separated and the aqueous phase wasextracted with ethyl acetate (20 ml) twice. The combined organic phases were washed withsaturated brine, dried over Na2SO4, and concentrated in vacuo. Then the crude product waspurified by column chromatography through silica gel, eluting with ethyl acetate/petroleum ethersolvent mixture, to give the pure product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhou, Guoquan; Chen, Wen; Zhang, Shihui; Liu, Xuemin; Yang, Zehui; Ge, Xin; Fan, Hua-Jun; Synlett; vol. 30; 2; (2019); p. 193 – 198;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com