Adding a certain compound to certain chemical reactions, such as: 13194-69-9, name is 2-Iodo-5-methylaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13194-69-9, Recommanded Product: 2-Iodo-5-methylaniline
The corresponding imidazopyridine compound (0.2 mmol) and cuprous iodide (0.02 mmol) were sequentially added to a 25 ml Schlenk tube filled with oxygen and equipped with a magnetic stirrer at room temperature.2-iodo-5-methylaniline (0.5 mmol),1,10-azaphenanthrene (0.06 mmol), DBU (0.8 mmol),Carbon disulfide (0.4 mmol) and toluene (2.0 mL) were added by syringe under oxygen.The reaction tube was placed in a 120 C oil bath and stirred for 7 hours. The resulting solution was cooled to room temperature, and 2 mL of deionized water was added to the reaction mixture, and the mixture was uniformly mixed.Each time, 3 mL of ethyl acetate was used as an extractant to perform a liquid separation extraction operation.The crude product is extracted from the reaction liquid, and the extract is combined, and the solvent is removed by a rotary evaporator; the residue is purified by a silica gel column (silica gel size: 200 mesh to 300 mesh,The eluent is petroleum ether/ethyl acetate (6:1 v/v)).The target product was obtained in 64.5 mg, yield 80%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Iodo-5-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; Qingdao University of Science and Technology; Yang Daoshan; Yan Qiuli; (17 pag.)CN110294757; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com