Electric Literature of 64248-58-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows.
Example 18 a) 7.40 g (62.5 mmol) of benzimidazole is added to 2.50 g (62.5 mmol) of 60 % sodium hydride in 100 ml of NMP at room temperature, then 7.50 g (31.3 mmol) of 1 ,2-difluoro-4- iodo-benzene is added at room temperature and stirred for 24 h at 190 C. The reaction mixture is cooled at room temperature and added water, then the precipitate is filterted off, washed with ethyl acetate and dried. Yield 10.8 g (79 %). 1 H NMR (400 MHz, CDCI3): delta 8.10 (d, J = 1.9 Hz, 1 H); 8.08 (dd, J = 8.3, 2.0 Hz, 1 H); 7.76 (dd, J = 7.9, 1 .1 Hz, 2H); 7.67 – 7.58 (m, 2H); 7.48 (d, J = 8.3 Hz, 1 H); 7.33 – 7.16 (m, 6H).
The chemical industry reduces the impact on the environment during synthesis 1,2-Difluoro-4-iodobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SAITO, Masatoshi; NAGASHIMA, Hideaki; (118 pag.)WO2017/178864; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com