Synthetic Route of 71838-16-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71838-16-9 name is 2-Bromo-1-iodo-4-methylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The 170mg (1mmol) 5- chlorobenzothiazole, 534 (1.8mmol) 4- bromo-1-iodo-toluene, 12.5mg (0.05mmol) CuSO4ยท5H2O14mg(0.1mmol)L1690mg(5mmol)K2CO3, 2gPEG100, was added 10mL reaction tube, sealed, under the reaction condition of 80 14h.After the reaction was stopped, extraction with ethyl acetate, washed with water, brine, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated under reduced pressure, column chromatography was purified by silica gel column to give 2-chloro-8-methyl-phenothiazine piperazine 161mg, yield 65%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-iodo-4-methylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; Sun Yat-sen University; Wan, Yiqian; Huang, Manna; Huang, Dongting; Zhu, Xinhai; (11 pag.)CN104529938; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com