Synthetic Route of 355-43-1, The chemical industry reduces the impact on the environment during synthesis 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, I believe this compound will play a more active role in future production and life.
In a typical procedure compound 2 (50.0 g, 0.147 mol), 10% aqueous solution of Na2S2O5 (140 mL) and perfluoro hexyl iodide (67.0 g, 0.150 mol) was added into a 1.0 L flask and the mixture heated at 80 C under stirring. AIBN (1.0 g, 6.1 mol) was slowly added (four portions of 0.2 g each in 1 h). It was left to react at 80 C for 3 h under stirring. At the end the organic phase containing 110.9 g (0.14 mol, Y = 96%) of 5 was separated from the aqueous one and washed with water. Compound 5 (20.0 g, 0.025 mol) was charged in the autoclave and a solution containing 70 mL ethylacetate, 50 mL methanol, and 7 g of sodium acetate was added; 1.0 g of Pd/C (10%) suspended in 20 mL of methanol was charged. The mixture was left to react at room temperature at a pressure of 3 bar of hydrogen for 15 h. The raw mixture was filtered and solvents were removed with rotary evaporation. Successively 100 mL of water and 100 mL of Et2O were added to the solid residue. The organic phase was dried with magnesium sulphate and the solvent layer was eliminated under rotary evaporation. The crude material was distilled under vacuum in order to obtain 13.5 g (0.020 mol) of product 8 with a yield of 82%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Lazzari, Dario; Cassani, Maria Cristina; Solinas, Gavino; Pretto, Marisa; Journal of Fluorine Chemistry; vol. 156; (2013); p. 34 – 37;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com