Adding a certain compound to certain chemical reactions, such as: 35944-64-0, name is 3-Iodo-4-methylaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35944-64-0, name: 3-Iodo-4-methylaniline
N-(3-Iodo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trfluoromethy1)benzamide: To a flask containing 1,0 g (2.67 mmol) of 4-[(4-methyl-1- piperazinyl)rnethyl]-3 -(trifluoromethyl)-benzoic acid (CAS 859027-02-4; prepared according toAsaki, T. et al. Bioorg. Med. Chem. Lelt. (2006), 16, 1421-1425), 0.62 g (2.67 mmol) of 3-lodo-4-methylanil me, 0.77 g (4.0 mmol) of N-(3 -dimethylaminopropyl)-N?-ethylcarbodi imide hydrochloride (EDAC), and 0.43 g (3.2 mmol) of N-hydroxybenzotriazole monohydrate (HOBt H20) was added 5 mL of DCM and 5 mL of triethylamine. The solution was stirred at ambient temperature under an atmosphere of N2 for 3 days, concentrated, and the crude product purified by silica gel chromatography (eluted with 100% EtOAc then 10% MeOH/EtOAc), to provide0.69 g of product as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodo-4-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; GOZGIT, Joseph, M.; RIVERA, Victor, M.; SHAKESPEARE, William, C.; ZHU, Xiaotian; DALGARNO, David, C.; WO2013/162727; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com