In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25309-64-2 as follows. Application In Synthesis of 1-Ethyl-4-iodobenzene
General procedure: To a round-bottom flask were charged with an N?-Boc-N-aryl hydrazine 7 or 14 (48 mmol), 4-substituent iodobenzene 8 (40 mmol), CuI (0.78 g, 4 mmol), 1,10-phenanthroline (1.44 g, 8 mmol), Cs2CO3 (15.64 g, 48 mmol) and 40 mL of dry DMF at room temperature. The reaction mixture was degassed, charged with N2 gas and heated to 80 C. After 4-5 h, the resulting mixture was cooled to room temperature, diluted with ethyl acetate (100 mL), filtered. The filtrate was then washed twice with brine (2×100 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure, The residue was purified by flash chromatography with a mixture of petroleum ether and ethyl acetate as an eluent to afford the desired product, which was recrystallized from a mixture of petroleum ether and ethyl acetate to give the desired crystals 9 or 15.
According to the analysis of related databases, 25309-64-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yang, Zhanhui; Hou, Shili; He, Wei; Cheng, Baoxiang; Jiao, Peng; Xu, Jiaxi; Tetrahedron; vol. 72; 17; (2016); p. 2186 – 2195;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com