1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-(4-Iodophenoxy)acetic acid
Example 3; A. Podophyllotoxin-4-O-ester of 4-iodophenoxyacetic acid (000614); The mixture of podophyllotoxin (41 mg, 0.1 mmol), 4-iodophenoxyacetic acid (55 mg, 0.2 mmol), EDCI (40 mg, 0.14 mmol), DMAP (2 mg, 0.02 mmol) and dichloromethane (5 ml) were stirred in the room temperature for 20 h, then dichloromethane (20 ml) was added to the solution. Organic layer was washed with water (20 ml), saturated NaHCO3 aqueous solution (10 ml) and brine (20 ml), and then dried over MgSO4. After the solvent was removed under reduced pressure, the resulting liquid was separated by column chromatography (eluent: ethyl acetate and petroleum ether) to afford 35 mg podophyllotoxin-4-O-4-iodophenoxyacetate, mp. The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz); delta 7.60 (t, 2H, Ar-H), 6.69 (d, 2H, Ar-H), 6.61 (s, 1H, Ar-H), 6.53 (s, 1H, Ar-H), 6.36 (s, 2H, Ar-H), 5.98 (d, 3H, OCH2O), 4.74 (q, 2H, COCH2O), 4.60 (d, 1H, H4), 4.34 (t, 1H, H11), 4.20 (t, 1H, H11), 3.81 (s, 3H, OCH3), 3.74 (s, 6H, OCH3), 2.91 (d, 1H, H2), 2.85 (m, 1H, H3).
The synthetic route of 1878-94-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yang, Li-Xi; US2005/4169; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com