Electric Literature of 135050-44-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 135050-44-1, name is 3-Chloro-4-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 3-chloro-4-iodobenzenamine (500 mg, 1.97 mmol), 4- chlorophenylboronic acid (324 mg, 2.07 mmol), Na2CO3 (627 mg, 5.92 mmol) andPd(PPh3)4 (228 mg, 0.20 mmol) in 1,4-dioxane (21 mL) and H20 (4 mL) was stirred at80 C under argon for 16 h. The mixture was allowed to cool to RT and concentrated invacuo. The residue was purified by flash column chromatography on silica gel (ethyl acetate / petroleum ether = 5/1) to afford the desired product (424 mg, 91% yield) as a yellow solid.
The chemical industry reduces the impact on the environment during synthesis 3-Chloro-4-iodoaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ARAXES PHARMA LLC; JANES, Matthew, Robert; PATRICELLI, Matthew, Peter; LI, Liansheng; REN, Pingda; LIU, Yi; (397 pag.)WO2016/44772; (2016); A1;,
Iodide – Wikipedia,
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