Synthetic Route of 401-81-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A Schlenk tube was charged with MCM-41-2N-CuI (66 mg,0.03 mmol), MeCSNH2(75 mg, 1.0 mmol), Cs2CO3(978 mg,3.0 mmol), and aryl halide (2.5 mmol). The tube was evacuated andbackfilled with argon. Then, DMSO-H2O (1 ml/0.5 ml) was addedunder argon. The tube was sealed, and the reaction mixture wasstirred at 120C for 24-48 h. The reaction mixture was cooled toroom temperature, diluted with ethyl acetate (10 ml), and filtered.The MCM-41-2N-CuI complex was washed with distilled water(2 × 5 ml), ethanol (2 × 5 ml), and Et2O (2 × 5 ml) and reused in thenext run. The filtrate was concentrated under reduced pressureand the residue was purified by flash column chromatography onsilica gel (petroleum/ethyl acetate = 50:1 to 7:1) to provide thedesired product.
The chemical industry reduces the impact on the environment during synthesis 1-Iodo-3-(trifluoromethyl)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Article; Cai, Mingzhong; Yao, Ruiya; Chen, Lin; Zhao, Hong; Journal of Molecular Catalysis A: Chemical; vol. 395; (2014); p. 349 – 354;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com