Adding a certain compound to certain chemical reactions, such as: 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-31-6, Product Details of 627-31-6
In a 250 mL single-necked flask, 1.0 g (6.75 mmol) of 2-methylbenzothiazepine, 6.0 g (20.3 mmol, 3 eq) of 1,3-diiodopropane, 40 mL of acetonitrile were added in sequence, under Ar gas protection and magnetic stirring. Under the conditions, the mixture was heated to reflux for 24 h. After the reaction solution was cooled, 50 mL of acetone was slowly added, and solids were precipitated under vigorous stirring, and filtered through a Buchner funnel to obtain 2.65 g of a solid yellow solid.The crude yield was 88.4%. The obtained crude product was recrystallized from ethanol and water (v/v = 1:1) to give 2260 mg of solid powder, intermediate of formula I, yield 75%
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Reference:
Patent; Shanghai Biological Chip Co., Ltd.; Han Junsong; Cui Lei; Xu Yichun; Yuan Qing; Zhou Jiajing; Yin Jiahui; (15 pag.)CN109796781; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com