Some common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Iodobenzenesulfonyl chloride
4-iodobenzenesulfonyl chloride (5.00 g, 16.5 mmol) was added to 250 mL dry three-necked flask and fluorobenzene (7.30 g, 76.0 mmol) was added and stirred.Add anhydrous aluminum chloride (3.31g, 24.8mmol), raise the temperature to 40 ~ 50 C, react 5 ~ 6h, after the reaction is over,Dichloromethane (50 mL) was added to a three-necked flask, dilute hydrochloric acid was slowly added, and stirring was continued until no precipitation was observed.Then, the reaction solution was poured into a separatory funnel, extracted three times with dichloromethane, and then washed with dilute hydrochloric acid for 2 to 3 times until the water layer became colorless.Dry the organic layer over anhydrous sodium sulfate.After filtration, the filtrate was spin-dried in a rotary evaporator to give 4.80 g of a yellow-white solid with a yield of 80%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 98-61-3, its application will become more common.
Reference:
Patent; Shenzhen Huaxing Optoelectric Co., Ltd.; Sun Yat-sen University; Li Xianjie; Wu Yuanjun; Lv Boyan; Yu Tao; Huang Qiuyi; Xie Zongliang; Ou Depei; Wang Leyu; Chi Zhenguo; Zhang Yi; Liu Siwei; Xu Jiarui; (15 pag.)CN108101941; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com