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Adding a certain compound to certain chemical reactions, such as: 627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-32-7, HPLC of Formula: C3H7IO
EXAMPLE 1Preparation of (9Z,i7E)-3-(nitrooxy)propyl octadeca-9,ll-dienoate (9Z, 11 E)-3-(nittauooxy)ptauopy octadeca-9,11-dienoate was synthesised in accordance with the procedure set out below:(A) To a solution of silver nitrate (5.34 g, 31.11 mmol) in acetonitrile (100 ml) was added dropwise via syringe 3-iodo-propan-l-ol (2.6 ml, 4.90 g, 26.33 mmol). The reaction mixture was stirred at room temperature for 48 h, then filtered over Celite. The filtrate was concentrated under reduced pressure and the residual oil was purified by flash chromatography (Petroleum Ether / EtOAc 7:3) yielding 3-hydroxypropyl nitrate as a brown oil (3.02 g, 24.95 mmol, 94 %), as shown below:AgNO3O2N(XMeCNRf 0.20 (Pet. Ether / EtOAc 7:3)Bp 56-58 C / 0.15 Torr (lit.)1H NMR 1.96 (p, 2H, J=6.2 Hz, CH2), 2.06 (s, IH, OH), 3.74 (dt, IH, J=2.2,6.1 Hz, CH2O), 4.59 (t, IH, 7=5.3 Hz, CH2ONO2)13C NMR 29.5 (CH2), 58.6 (CH2O), 70.2 (CH2ONO2) IR 1283, 1634, 3368Mass 122 (M+ 1, 10 %), 104 (16 %), 75 (17 %), 59 (27 %), 46 (100 %)
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Reference:
Patent; UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND; WO2009/127398; (2009); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com