1643-29-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
lntermediate-2; Methyl 3-(4-iodophenyl)propanoate.; Methanol (5 ml.) under nitrogen at O0C was added AcCI (0.4 ml_, 5.63 mmol). The reaction was stirred for 10 min before slow addition of 3-(4-iodophenyl)propanoic acid (498 mg, 1.80 mmol). The reaction was stirred for additional VA hour at room temperature, before the mixture was concentrated under vacuum, re-dissolved in MeOH and concentrated to give 512 mg (98%) of a pure white solid. Rf: 0.39 (EtOAc:hexanes, 1 :4); 1HNMR (CDCI3) delta 7.61-7.59 (m, 2H), 6.97- 6.94 (m, 2H), 3.66 (s, 3H), 2.92-2.87 (t, 2H, J = 7.5 Hz), 2.63-2.58 (t, 2H, J = 7.5 Hz); 13CNMR (CDCI3) delta 173.0, 140.1 , 137.5, 130.4, 91.4, 51.7, 35.4, 30.4; EI-MS m/z 290.0 (MH+).
The synthetic route of 3-(4-Iodophenyl)propanoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYDDANSK UNIVERSITET; ULVEN, Trond; CHRISTIANSEN, Elisabeth; WO2010/12650; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com