Electric Literature of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The air was exchanged 3 times with nitrogen in a 25 mL test tube reactor. The first step was to first substrate 1a (0.2 mmol, 57.1 mg), pinacol borate (0.4 mmol, 102 mg), Pd (PPh3) 4 (0.02 mmol, 23.1 mg), cesium carbonate (0.4 mmol, 130 mg) Weighed into the reaction tube, vacuumed for nitrogen, and added tetrahydrofuran (2 mL) and water (0.014 mL) under nitrogen, and the reaction was heated to 60 C for 12 hours; the second step was added for 2 hours ( 0.24 mmol,65.5 mg) continued to react at this temperature for 12 hours. After TLC detects the reaction,The system was cooled to room temperature. Directly add silica gel, spin dry column chromatography,Obtained a reddish brown solid 3ah (41%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dichloro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shandong University of Technology; Liu Hui; Cui Jie; Meng Long; Chi Xiaochen; Sun Xi; Cao Chengqiang; Liu Qing; Li Xinjin; Zhou Zhen; Dong Yunhui; (16 pag.)CN109553555; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com