Adding a certain compound to certain chemical reactions, such as: 351003-36-6, name is 2-Fluoro-5-iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 351003-36-6, 351003-36-6
Step 2: lambda/-r3-(3-Cvano-4-fluorophenyl)prop-2-vti-l-yll-N-(2,4-dimethoxybenzyl)-lH-pyrrole-2- carboxamide (A2)To a solution of Al (1 eq) in a mixture of DMF and Et3N (1:1) was added 2-fluoro-5- iodobenzonitrile (2 eq), CuI (0.2 eq) and Pd(PPh3)4 (0.05 eq). The resulting mixture was stirred at RT overnight. The reaction mixture was diluted with EtOAc, washed with 0. IN HCl (2x) and then with brine; dried (Na2SO4) and concentrated. The resulting crude was purified by on silica gel eluting with EtO Ac/petrol ether to obtain the desired compound. MS (ES) C24H2OFN3O3 requires: 417, found: 418 (M+H)+. 1R NMR (400 MHz, DMSOd6) delta: 11.59 (IH, bs), 7.93 (IH, dd, J = 6.3, 2.0 Hz), 7.78-7.73 (IH, m), 7.53 (IH, t, J = 9.1 Hz), 7.13 (IH, d, J = 8.3 Hz), 6.93 (IH, s), 6.60 (IH, d, J = 2.3 Hz), 6.53 (IH, dd, J = 8.3, 2.3 Hz), 6.50-6.38 (IH, m), 6.10 (IH, s), 4.77 (2H, s), 4.50 (2H, s), 3.78 (3H, s), 3.76 (3H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-5-iodobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/138355; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com