112671-42-8,Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate Ml-a (5. lg, 18.4 mmol) and 2_p_5_ nitrobenzene (15.3 g, 46.7 mmol), tert-butanol sodium (7. lg, 74.4 mmol), toluene 100 mL, nitrogen Protection, 0.3g Pd2 (dba) 3, tri-tert-butylphosphine (20ml, 10% toluene solution), start stirring, heat to 100 C reflux, reaction 12h, the reaction liquid is washed, the organic phase is concentrated, passed through the silica gel column, rinse The oil was petroleum ether: ethyl acetate = 50:1, and the eluent was concentrated to give intermediate Ml-b (9.2 g, yield: 7.39 %).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-iodo-2-nitrobenzene, its application will become more common.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Zhang Yaguang; Zhang Xianghui; Ren Xueyan; (28 pag.)CN108341826; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com