Some common heterocyclic compound, 71838-16-9, name is 2-Bromo-1-iodo-4-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 71838-16-9
Add 2,4-dimethylaniline 37 g (186 mmol, 1 eq), 2-bromo-4-methyliodobenzene 50 g (216 mmol) to a 1000 mL three-necked flask equipped with magnetic stirring at room temperature. , 1.16eq), pd2(dba)3 1.7g (18.6mmol, 1% eq), dppf 2.06g (3.7mmol, 2% eq), sodium tert-butoxide 27g (279mmol, 1.5eq), toluene 500mL, plus The nitrogen gas was replaced 3 times, stirring was started, and the oil bath was heated to reflux (oil bath temperature 120 C) for 5 hours. The TLC tracking reaction showed that the 2,4-dimethylaniline reaction was complete (PE/EA = 20:1) and the reaction was stopped.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 71838-16-9, its application will become more common.
Reference:
Patent; Gu’an Dingcai Technology Co., Ltd.; Beijing Dingcai Technology Co., Ltd.; Gao Wenzheng; Fan Hongtao; Ren Xueyan; (25 pag.)CN109206359; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com