Synthetic Route of 56404-21-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56404-21-8, name is 1-Iodo-2,4-dimethyl-3-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Scheme 4, Step B: To a 2 L Parr autoclave with mechanical stirring is added 1-iodo-2,4-dimethyl-3-nitro-benzene (70 g, 252.7 mmol), Pd(OAc)2 (2.8 g, 12.6 mmol),1 ,4-bis( diphenylphosphino )butane ( 6.5 g, 15.2 mmol), acetonitrile ( 462 mL ),triethylamine (88.2 mL), and methanol (280 mL). The Parr autoclave is sealed, purgedand pressurized with CO to 551.6 kPa (80 psig). The mixture is heated to 100C for 2hours. The mixture is cooled to ambient temperature and then vented. The mixture isthen concentrated to dryness under reduced pressure. Ethyl acetate (300 mL) and water(300 mL) are added. The layers are separated and the aqueous layer discarded. The organic layer is dried over MgS04, filtered, and concentrated to dryness to afford the title20compound as a red oil which crystallizes upon standing (52 g, 98 %). 1 H NMR (300.13MHz, CDCl3): o 7.89 (d, J= 8.2 Hz, 1H), 7.19 (d, J= 8.2 Hz, 1H), 3.91 (s, 3H), 2.49 (s,3H), 2.33 (s, 3H).
The synthetic route of 1-Iodo-2,4-dimethyl-3-nitrobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee; WO2014/4230; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com