Related Products of 52548-14-8, These common heterocyclic compound, 52548-14-8, name is 2-Iodo-5-methylbenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-lodo-5-methylbenzoic acid (101 g; 387 mmol) is dissolved in MeOH (700 ml) followed by the addition of concentrated sulfuric acid (97%; 10.4 ml; 193 mmol). The reaction mixture is heated to 83C for 16 hours, cooled again to RT followed by slow and careful addition of aq. 1 M NaOH solution until pH 8 is reached. The MeOH is evaporated under reduced pressure and the remaining aq. phase is extracted with DCM (2x 350 ml). The combined organiclayers are washed with water (400 ml), dried over Mg504, filtered and the solvent is evaporated under reduced pressure to give 104.13 g of the title compound as a yellow liquid. tR [mm] = 0.89; [M+H] = not detected.
Statistics shows that 2-Iodo-5-methylbenzoic acid is playing an increasingly important role. we look forward to future research findings about 52548-14-8.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOSS, Christoph; BRISBARE-ROCH, Catherine; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; JENCK, Francois; SIFFERLEN, Thierry; STEINER, Michel; WILLIAMS, Jodi; WO2015/83094; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com