Adding a certain compound to certain chemical reactions, such as: 6828-35-9, name is 5-Chloro-2-iodoaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6828-35-9, category: iodides-buliding-blocks
In a round bottom flask, 5-chloro-2-iodoaniline (2.00 g, 7.89 mmol), methyl propargylether (1.00 mL, 11.84 mmol) and TEA (1.92 mL, 13.41 mmol) were diluted in DMF.The mixture was degassed (N2 bubbling) and Pd(PPh3)2C12 (0.28 g, 0.39 mmol) andCul (0.30 g, 1.58 mmol) were added. The reaction mixture was stirred at rt for 4 h.Thereaction mixture was aprtitionned between water and EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated. The crude was purified by column chromatography on silica gel (irregular Si02, 40 g, mobile phase:heptane/EtOAc, gradient from 90:10 to 80:20). The product fractions were concentrated to afford 1.0 13 g of intermediate 376 (70% yield, orange liquid which solidify upon standing).
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Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; PONCELET, Virginie Sophie; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (477 pag.)WO2017/125530; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com