Electric Literature of 51628-12-7, The chemical industry reduces the impact on the environment during synthesis 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, I believe this compound will play a more active role in future production and life.
To a stirred solution of 2-(4-iodophenyl)acetonitrile (10 g, 41 .15 mmol) in tetrahydrofuran (100 ml) was added drop wise lithium bis(trimethylsilyl)amide (103 ml of a 1 M solution in tetrahydrofuran, 103 mmol) at -78 C. The resulting mixture was allowed to stirre for 15 minutes. The 3-(chloromethyl)pyridine hydrochloride (6.75 g, 41.15 mmol) was then added. The reaction was then allowed to react overnight at room temperature. The reaction was monitored by thin layer chromatography and showed completion after one night of stirring. Water (100 ml) and ethyl acetate (100 ml) were added. The organic phase was isolated and concentrated under reduced pressure The crude product was then absorbed onto silica gel and purified by flash chromatography to give 4.7 g of 2-(4-iodophenyl)-3-(3- pyridyl)propanenitrile
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Iodophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JEANMART, Stephane Andre Marie; RAJAN, Ramya; BONVALOT, Damien; PERRUCCIO, Francesca; WO2015/14733; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com