Synthetic Route of 52548-63-7, These common heterocyclic compound, 52548-63-7, name is 5-Fluoro-2-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General Method CTo the stirred solution of starting material (0.10 mmol, 1 equiv.) in DMF (8 mL) were added the acid (0.11 mmol, 1.1 equiv.), HATU (0.12 mmol, 1.2 equiv.) and DIPEA (0.40 mmol, 4 equiv.) at 0 C. After stirring for 30 min at room temperature, the reaction mixture was diluted with water (10 mL) and then extracted with ethyl acetate (10 mL x 2). The combined organic layers were washed with brine (10 mL) and dried over Na2S04. After removal of solvent under reduced pressure, the residue was purified by either column chromatography (silica gel, petroleum ether/ethyl acetate: 5/1) or prep-HPLC to afford the target.
Statistics shows that 5-Fluoro-2-iodobenzoic acid is playing an increasingly important role. we look forward to future research findings about 52548-63-7.
Reference:
Patent; EOLAS THERAPEUTICS, INC.; KAMENECKA, Theodore M.; HE, Yuanjun; (105 pag.)WO2016/25669; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com