In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-77-3, name is 1,5-Diiodopentane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: iodides-buliding-blocks
Diiodopentane (1.07 mL, 7.2 mmol, 5 eq) and potassium carbonate (200 mg, 1.44 mmol, 1 eq) were added to a solution of phenol 40 (800 mg, 1 .44 mmol) in acetone (8 mL, dried over molecular sieves). The reaction mixture was then warmed to 60C and stirred for 6 hours. Acetone was removed by rotary evaporation under reduced pressure. The resulting residue was subjected to flash column chromatography (silica gel; 50/50, v/v, hexane/ethyl acetate,). Pure fractions were collected and combined and excess eluent was removed to provide 41 (800 mg, 74%). LC/MS, method 2, 4.00 min (ES+) m/z (relative intensity) 750.66 ([M+H]+, 100).
The synthetic route of 628-77-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SPIROGEN SARL; HOWARD, Philip Wilson; TIBERGHIEN, Arnaud; WO2013/53872; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com