Reference of 76801-93-9, These common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
According to the compound of formula 1 and 3-chloro-1,2-propanediol,The molar ratio of sodium methoxide is 1:1:1.50 g of Compound Formula 1, 60 mL of methanol and 4.54 g of sodium methoxide were added to the reaction flask.3-chloro-1,2-propanediol 9.24g,Heat to 20-60 C for 10-20 hours.Distill off methanol and add 50 mL of water.Adjust the pH to 5-7 with hydrochloric acid,Add 80 mL of isopropanol and cool to 0-10 C.Precipitating crystals,dry,5-(2,3-Dihydroxypropyl)amino-N,N’-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-phthalamide solid (compound of formula 8),The purity is 95.6%.
The synthetic route of 76801-93-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Brethren Technology Co., Ltd.; Zhan Guowu; Xiong Anwei; Zhou Zhongping; Qian Zhida; (9 pag.)CN109912445; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com