Application of 58313-23-8,Some common heterocyclic compound, 58313-23-8, name is Ethyl-3-iodobenzoate, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 83; (IS, 2R) and (1R, 2S)-3-(2-(4-chlorophenyl)-2′-oxospiro[cyclopropane-l,3′-indoline]- l’-yl)benzoic acid; Synthesis of (IS, 2R) and (1R, 2S)-methyl-3-(2-(4-chlorophoxospiro[cyclopropane-l,3′-indoline]-l’-yl)benzoateA Schlenk tube was charged with Cul (9.6 mg, 0.05 mmol, 5.0 mol %), racemic (1R, 2S) and (I S, 2R)-2-(4-chlorophenyl)spiro[cyclopropane-l,3′-indolin]-2′-one (270 mg, 1.0 mmol), and K2C03 (276 mg, 2.0 mmol), evacuated, and backfilled with argon. N, iV- Dimethylethylenediamine (1 1 /L, 0.10 mmol, 10 mol %), ethyl 3-iodobenzoate (278.8 mg, 1.01 mmol), and acetonitrile (1.5 mL) were added under argon. The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at 80 C for 23 hours. HPLC monitored the reaction finished. The solvent was removed under reduced pressure. The residue was purified by flash column chromatography column (gradient elution, 5-10 % ethyl acetate in petroleum ether) to give the title compound as a yellow powder (290 mg, 72 %). LC/MS m/e calcd. for C24Hi8ClN03: 403, observed (M+H)+: 404.1.
The synthetic route of 58313-23-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HUANG, Mengwei; FENG, Lichun; HE, Yun; YUN, Hongying; WO2011/69298; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com