These common heterocyclic compound, 619-58-9, name is 4-Iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks
General procedure: A typical method for preparation of phenols: A Schlenk test tube with a magnetic stirring bar was charged with CuSO4·5H2O (13 mg, 5 mol %), NaAsc (20 mg, 10 mol %), benzene halide (1.0 mmol), KOH (168-336 mg, 3.0-6.0 equiv) in DMSO/H2O (v/v=1:1, 3.0 mL) at 120 C for 24h. After cooling to room temperature, carefully acidified with dilute aqueous HCl to pH=2-3 and the mixture were stirred for half hour. Then the resultant mixture was extracted with EtOAc (3×20 mL). The combined organic layers were washed with brine (20 mL) and dried over Na2SO4. Purification via silica gel column chromatography with a mixture of ethyl acetate/petroleum ether. Details as follows:
The synthetic route of 4-Iodobenzoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Article; Song, Guang-Lin; Zhang, Zhang; Da, Yu-Xia; Wang, Xi-Cun; Tetrahedron; vol. 71; 46; (2015); p. 8823 – 8829;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com