A common compound: 628-21-7, name is 1,4-Diiodobutane, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 628-21-7
Preparatory Example 7 Spiro[cyclopentane-1,3′-indolin]-2′-one n-Butyl lithium (2.5 M in hexanes, 4.2 mL, 0.5 mmol) was added dropwise to a suspension of indolinone (0.665 mg, 5 mmol) and TMEDA (1.5 mL, 10 mmol) in THF (20 mL) at -78 C. in a dried flask under nitrogen. After 1 hour at -78 C., 1,4-diiodobutane (3.3 mL, 25 mmol) was added dropwise and the mixture was allowed to slowly warm to rt. After 12 hours at rt, saturated aqueous ammonium chloride was added to the mixture and this mixture was extracted with EtOAc. The combined organic phases were washed with water, brine, dried over magnesium sulphate, filtered and concentrated in vacuo. Chromatography on silica (10-30% EtOAc in isohexane) gave isolation of the desired compound as a pale pink solid (393 mg, 2.1 mmol, 42%). 1H NMR (400 MHz): delta 1.90 (m, 2H), 2.03 (m, 2H), 2.10 (m, 2H), 2.21 (m, 2H), 6.94 (m, 1H), 7.04 (m, 1H), 7.20 (m, 2H), 8.75 (bs, 1H). LC/MS 188 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 628-21-7, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; re: Viral Ltd; Cockerill, Stuart; Pilkington, Christopher; Lumley, James; Angell, Richard; Mathews, Neil; US2014/308282; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com