Some common heterocyclic compound, 13101-40-1, name is 1-Bromo-3-chloro-5-iodobenzene, molecular formula is C6H3BrClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 13101-40-1
A mixture of 1-bromo-3-chloro-5-iodobenzene (1.5 g, 4.73 mmol), 4-(2,6-diisopropylphenyl)-1H-pyrazole (1.133 g, 4.96 mmol), 63 copper chloride dihydrate (0.161 g, 0.945 mmol), and 64 cesium carbonate (3.08 g, 9.45 mmol) was vacuumed and back-filled with nitrogen several times. 65 DMF (20 ml) was added to the reaction mixture and heated at 120 C. for 18 h. Cooled down and partitioned between EA and water and extracted with EA with a bit of NH4OH(aq). The organic portion was washed with brine and concentrated. Chromatographed on silica (DCM/Hep=2/1). Obtained white solid (73%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13101-40-1, its application will become more common.
Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; CHEN, Hsiao-Fan; (99 pag.)US2019/165284; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com