Application of 19231-06-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19231-06-2 name is Bis(4-methoxyphenyl)iodonium bromide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
107.2 g obtained in step (1) was added to the reactor.3,5-diiodo-L-tyrosine copper complex and 1000 ml of water,Then slowly add 1200ml of n-butanol to the inside.After the dropwise addition within 1 h, the reaction was dissolved. Then add 43.8g of diisopropylamineThereafter, 146 g of diphenyl methyl ether iodide bromide was further added. The reaction solution was heated to 90 C, and reacted at 90 C for 2 h, cooled to room temperature, and 280 ml of toluene was added. An additional 200 ml of 10% citric acid solution was added and stirred at room temperature for 2 h, filtered, washed with water and methyl isobutyl ketone. The obtained wet cake was further added with 400 ml of 10% citric acid solution and stirred for 1 h, filtered, and washed with 10% citric acid solution.Drying to give 2-amino-3-(3,5-diiodo-4-(4-methoxyphenoxy)phenyl)propionic acid (compound of formula III) 69.1 g,The yield was 59.3%, and it was used.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Bis(4-methoxyphenyl)iodonium bromide, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing Tech University; Lu Dingqiang; Chen Li; Wang Xinxian; Ye Hui; (10 pag.)CN109810009; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com