In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 172681-47-9, name is 2-Amino-6-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Amino-6-iodotoluene
B2pin2 (140 mg, 0.55mmol, 1.1 equiv) and aniline 17 (117 mg, 0.5 mmol, 1.0 equiv) were weighed in a 25mL round-bottom flask. MeCN (2mL) and t-BuONO (86 mg, 0.75 mmol, 1.5 equiv) were then added insuccession. The resulting reaction solution was stirred for 3 h at 80 C (N2 evolution completed within 5 to15 min). The solution was then concentrated under reduced pressure, and the crude residue was purifiedby flash chromatography (silica gel, hexane/EtOAc = 40:1) to give pinacol boronate ester 18 (91.2 mg) in53% yield. The following deprotection and dean-stark procedure was same as preparing 1t.23
The synthetic route of 172681-47-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Renhe; Liu, Feipeng; Dong, Guangbin; Chem; vol. 5; 4; (2019); p. 929 – 939;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com