Application of 180624-10-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 180624-10-6, name is Methyl 4-amino-3-iodo-5-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 43-1 (2.5 g, 4.1 mmol), CuCN (1.46 g, 8.2 mmol) in DMF (15 mL*2) was heated to 120 C. and stirred for 1 h under microwave irradiation. The mixture was poured into water (50 mL) and extracted with EA (2×50 mL). The organic phase was concentrated, and the residue was purified by column chromatography using 520% EA in PE to give 43-2 (1.6 g, 95.3%) as a yellow solid. MS: m/z 206.9 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis Methyl 4-amino-3-iodo-5-methoxybenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Alios BioPharma, Inc.; Wang, Guangyi; Beigelman, Leonid; Truong, Anh; Stein, Karin Ann; (234 pag.)US2016/244460; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com