Electric Literature of 1032231-24-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1032231-24-5 name is 2-Bromo-5-iodobenzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Diethylaminosulfur trifiuoride (77.8 g, 482 mmol) was added to a solution of 2-bromo- iodobenzaidehyde (100 g, 322 mmol) and DCM (1 L) at 0 C. The resultant mixture was stirred at room temperature for 2 h before quenching with ice/water (1 L) and extracting with DCM (800 mL x 3). The combined organic extracts were washed with brine, dried over anhydrous Na?S04, filtered and concentrated to dryness to give the crude product, which was purified by FCC on silica gel (PE/EtOAc = 50: 1) to afford the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-iodobenzaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; STEENECK, Christoph; GEGE, Christian; KINZEL, Olaf; KLEYMANN, Gerald; HOFFMANN, Thomas; GOLDBERG, Steven; (220 pag.)WO2016/69976; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com